Disease-resistant poultry solution for virus issues

Developing animals resistant to disease may be one of the long-term solutions for poultry diseases. University of Georgia researchers in the Regenerative Bioscience Center have spent the last four years gathering data that could make the process a reality.

The team, which includes Steven Stice and Franklin West in the College of Agricultural and Environmental Sciences and Claudio Afonso at the Southeast Poultry Research Laboratory of the US Department of Agriculture’s Agricultural Research Service, used a technology platform called shRNA – single strands of RNA that fold back on themselves – to selectively stop the production of nucleic acids that cause disease, such as the Newcastle disease virus. Newcastle disease is a worldwide problem and is caused by one of the most deadly of all viruses that spreads between birds. Exotic Newcastle virus, the most devastating form of the virus, has been eradicated in the US and Canada. The milder forms of Newcastle are kept under control using vaccines.

Better way of disease protection than vaccination

The research team’s tooling process for enhancing disease resistance, published recently in the Journal of the International Alliance for Biological Standardisation, is potentially a much better way of disease protection than vaccination, because it introduces permanent genetic resistance that is transmittable to a bird’s offspring, the researchers said. In contrast, many vaccines provide protection for a given period of time and must be re-administered periodically.

“With this technology, we can target specific regions used by the Newcastle disease virus that are critical for its survival,” said Stice, a Georgia Research Alliance Eminent Scholar and director of the Regenerative Bioscience Center. “Preventing these lethal viruses from replicating in individual chickens may in the end reduce the overall level of virus transmission from one chicken to the next.”

Never vaccinate again

Multiple types of animals and disease could be targeted. This technology could also be applied to avian influenza and swine flu.

“Ultimately, you could have birds that are both avian influenza resistant and Newcastle disease virus resistant,” said West, an assistant professor in the animal and dairy science department. “Theoretically, you may never have to vaccinate again.”

Organised distribution of vaccine products can also present problems, especially in countries where farmers may not have a refrigerator or other means to store the vaccines at the temperature needed to keep the vaccine alive. This is particularly true in rural areas where backyard flocks may be a farmer’s main source of income.

Shipping disease-resistant chickens produced here in the US could be the best possible solution for many countries, Stice said. “We’ve taken many years to prove that this technology is viable,” he continued, “and we’re now ready to expand our work to the next stage.”

Source: University of Georgia