This video will discuss if resistance is an issue for anticoccidials (potent chemicals vs ionophores).
It is definitely an issue for chemicals because they have a simple mode of action, often blocking just a single enzyme and an essential biochemical pathway within the coccidia. The coccidia then need only very few genetic changes, sometimes only a single mutation to escape this anticoccidial activity. Chemicals also exercise strong selection pressure giving the resistant coccidia a reproductive advantage over drug-sensitive coccidia allowing them to rapidly become the predominant part of the coccidia population in the broiler facility.
Ionophores are much for difficult to develop resistance because of their complex mode of action coupled with the fact that they allow a few coccidia to cycle thus exercising less selection pressure than the chemicals.
Take a look back at the other videos from the series:
Video 1: Quantifying the costs of coccidiosis
Video 2: Measuring the efficacy of an anticoccidial
Video 3: Evaluating chemicals for coccidiosis control and prevention
Video 4: Evaluating vaccines as a coccidiosis control option
Video 5: Using ionophores to provide long-term control of intestinal integrity
Video 6: Understanding ionophore-nicarbazin combinations
Video 7: Synergistic success of narasin and nicarbazin
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Intestinal Integrity Corner, produced by Elanco, brings you insights into threats to broiler gut health and how to mitigate them with strategies for prevention, management and disease treatment that reduce reliance on medically important antibiotics. Elanco is committed to the poultry industry, delivering important scientific information about Intestinal Integrity, technical expertise, customer support and proven products such as Maxiban and Monteban. Maxiban and Monteban together form a trusted solution to maintain optimal enteric health resulting in efficient, healthy birds to promote safer food, better economic return and more brand assurance. Elanco is a global animal health company that develops products and knowledge services to prevent and treat disease in farm animals and pets in more than 90 countries. Elanco creates innovative solutions through products and services that address the challenges of an ever-changing world and empower those who raise and care for animals. Visit the Elanco website for more information
Intestinal Integrity Corner, produced by Elanco, brings you insights into threats to broiler gut health and how to mitigate them with strategies for prevention, management and disease treatment that reduce reliance on medically important antibiotics. Elanco is committed to the poultry industry, delivering important scientific information about Intestinal Integrity, technical expertise, customer support and proven products such as Maxiban and Monteban. Maxiban and Monteban together form a trusted solution to maintain optimal enteric health resulting in efficient, healthy birds to promote safer food, better economic return and more brand assurance. Elanco is a global animal health company that develops products and knowledge services to prevent and treat disease in farm animals and pets in more than 90 countries. Elanco creates innovative solutions through products and services that address the challenges of an ever-changing world and empower those who raise and care for animals. Visit the Elanco website for more information
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